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Title: Chroman and chromene derivatives as tumor multidrug resistance inhibitor as well as preparation method and application of chroman and chromene derivatives
Other Titles: 一种抗肿瘤多药耐药抑制剂色满和色烯衍生物及其制备方法和应用
Authors: Wan, S 
Zhou, M 
Yuan, J 
Huang, L
Jiang, T 
Li, X 
Zhang, X 
Sun, D 
Issue Date: 2-Jul-2014
Source: 中国专利 ZL 201210045877.3 How to cite?
Abstract: The invention provides chroman and chromene derivatives as tumor multidrug resistance inhibitors as well as a preparation method of the chroman and chromene derivatives. The chroman and chromene derivatives are represented by the following general formulae I and II respectively, wherein R is one or more of hydrogen, hydroxy, alkoxy, alkyl amino, alkyl acylamino, halogen, fluorine-containing alkyl or benzoyl; the benzoyl contains one or more of substituent groups of hydroxy, alkoxy, alkyl amino, alkyl acylamino, halogen or fluorine-containing alkyl; the alkyls in the alkoxy, the alkyl amino, the fluorine-containing alkyl and the alkyl acylamino are linear-chain or branch-chain alkyls with 1-10 carbon atoms; X is hydrogen or oxygen; and Y is oxygen or nitrogen. The chroman and chromene derivatives have low toxicity and good tumor multidrug resistance inhibiting activities, and can be used for preparing drugs for treating breast cancer, colon cancer, prostate cancer, leukemia, myeloma, pancreatic cancer and the like.
Rights: Assignee: 中国海洋大学
Assignee: 香港理工大学
Appears in Collections:Patent

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