Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/76471
Title: Electrospray-mediated preparation of compositionally homogeneous core-shell hydrogel microspheres for sustained drug release
Authors: Lai, WF 
Susha, AS
Rogach, AL
Wang, GA
Huang, MJ
Hu, WJ
Wong, WT 
Issue Date: 2017
Publisher: Royal Society of Chemistry
Source: RSC advances, 2017, v. 7, no. 70, p. 44482-44491 How to cite?
Journal: RSC advances 
Abstract: Incorporating hydrogel particles with the core-shell architecture is a promising route to fabricate colloidal "smart gels" with tuneable properties. This study reports a facile electrospray-based method to generate compositionally homogeneous core-shell hydrogel microspheres. By manipulating different process parameters (e.g., electric field strength, flow rate, and gel-forming polymer concentration), the size of the microspheres can be tuned from microns to millimetres. Drug release studies demonstrate that coating the surface of the hydrogel microsphere with a hydrogel layer remarkably prolongs the drug release sustainability. In 3T3 and HEK293 cells, both the acute and delayed toxicity caused by the hydrogel microspheres are shown to be negligible. Together with the ease of operation of the production method, the compositionally homogeneous core-shell microspheres generated by our method may enhance the versatility and flexibility in future drug delivery.
URI: http://hdl.handle.net/10397/76471
ISSN: 2046-2069
EISSN: 2046-2069
DOI: 10.1039/c7ra07568e
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

Page view(s)

10
Citations as of Nov 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.