Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/76417
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dc.contributor.authorYeung, WFen_US
dc.contributor.authorChung, KFen_US
dc.contributor.authorZhang, ZJen_US
dc.contributor.authorChan, WCen_US
dc.contributor.authorZhang, SPen_US
dc.contributor.authorNg, RMKen_US
dc.contributor.authorChan, CLWen_US
dc.contributor.authorHo, LMen_US
dc.contributor.authorYu, YMen_US
dc.contributor.authorLao, LXen_US
dc.date.accessioned2018-05-10T02:55:57Z-
dc.date.available2018-05-10T02:55:57Z-
dc.date.issued2017-
dc.identifier.citationBMC complementary and alternative medicine, 2017, v. 17, 183, p. 1-9en_US
dc.identifier.issn1472-6882-
dc.identifier.urihttp://hdl.handle.net/10397/76417-
dc.description.abstractBackground: Conventional approaches for benzodiazepine tapering have their limitations. Anecdotal studies have shown that acupuncture is a potential treatment for facilitating successful benzodiazepine tapering. As of today, there was no randomized controlled trial examining its efficacy and safety. The purpose of the study is to evaluate the efficacy of using electroacupuncture as an adjunct treatment to gradual tapering of benzodiazepine doses in complete benzodiazepine cessation in long-term benzodiazepine users. Methods/Design: The study protocol of a randomized, assessor- and subject-blinded, controlled trial is presented. One hundred and forty-four patients with histories of using benzodiazepines in >= 50% of days for more than 3 months will be randomly assigned in a 1: 1 ratio to receive either electroacupuncture or placebo electroacupuncture combined with gradual benzodiazepine tapering schedule. Both experimental and placebo treatments will be delivered twice per week for 4 weeks. Major assessments will be conducted at baseline, week 6 and week 16 post-randomization. Primary outcome is the cessation rate of benzodiazepine use. Secondary outcomes include the percentage change in the doses of benzodiazepine usage and the severity of withdrawal symptoms experienced based on the Benzodiazepine Withdrawal Symptom Questionnaire, insomnia as measured by the Insomnia Severity Index, and anxiety and depressive symptoms as evaluated by the Hospital Anxiety and Depression Scale. Adverse events will also be measured at each study visit. Discussion: Results of this study will provide high quality evidence of the efficacy and safety of electroacupuncture as an adjunct treatment for benzodiazepine tapering in long-term users.en_US
dc.description.sponsorshipSchool of Nursingen_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofBMC complementary and alternative medicineen_US
dc.rights© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
dc.rightsThe following publication Yeung, W. F., Chung, K. F., Zhang, Z. J., Chan, W. C., Zhang, S. P., Ng, R. M. K., … Lao, L. X. (2017). Electroacupuncture for tapering off long-term benzodiazepine use : study protocol of randomized controlled trial. BMC Complementary and Alternative Medicine, 17, 183, 1-9 is available at https://dx.doi.org/10.1186/s12906-017-1692-5en_US
dc.subjectBenzodiazepine discontinuationen_US
dc.subjectWithdrawalen_US
dc.subjectAcupunctureen_US
dc.subjectShamen_US
dc.subjectRCTen_US
dc.titleElectroacupuncture for tapering off long-term benzodiazepine use : study protocol of randomized controlled trialen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.epage9-
dc.identifier.volume17-
dc.identifier.doi10.1186/s12906-017-1692-5-
dc.identifier.isiWOS:000397787200003-
dc.identifier.pmid28359309-
dc.identifier.eissn1472-6882-
dc.identifier.artn183-
dc.description.validate201805 bcrc-
dc.description.oapublished_final-
Appears in Collections:Journal/Magazine Article
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