Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/76375
Title: Study of the aggregation of DNA-capped gold nanoparticles : a smart and flexible aptasensor for spermine sensing
Authors: Tsoi, TH 
Gu, YJ 
Lo, WS 
Wong, WT 
Wong, WT 
Ng, CF
Lee, CS
Wong, KL
Keywords: DNA
Gold
Nanoparticles
Spermine
Urine
Issue Date: 2017
Publisher: John Wiley & Sons
Source: Chempluschem, 2017, v. 82, no. 5, p. 802-809 How to cite?
Journal: Chempluschem 
Abstract: A smart gold nanoparticle based aptasensor is developed for the sensing of this biomarker in a convenient and fast manner. A comprehensive study was performed to elucidate the driving force of DNA adsorption, different factors' effects, such as gold nanoparticle size, DNA length, concentration, and working pH towards spermine sensing by using UV/Vis absorption spectroscopy and isothermal titration calorimetry. It was found that the developed aptasensor could detect spermine by two different sensing mechanisms simply by adjusting the DNA concentration without complicated procedures. Good performance in complicated matrices was proven by the satisfactory results obtained in the spike analysis of both artificial urine and clinical urine samples. Such a flexible and smart approach described here would provide a useful tool for the fast sensing of spermine and prostate cancer screening.
URI: http://hdl.handle.net/10397/76375
ISSN: 2192-6506
EISSN: 2192-6506
DOI: 10.1002/cplu.201700155
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