Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/76359
Title: An efficient nickel-catalyzed asymmetric oxazole-forming Ugi-type reaction for the synthesis of chiral aryl-substituted THIQ rings
Authors: Li, D
Yang, DX
Wang, LQ
Liu, XH
Wang, KZ
Wang, J
Wang, PX
Liu, YY
Zhu, HY
Wang, R 
Keywords: Chirality
Nickel
Oxazole
Tetrahydroquinoline
Ugi reaction
Issue Date: 2017
Publisher: Wiley-VCH
Source: Chemistry - a European journal, 2017, v. 23, no. 29, p. 6974-6978 How to cite?
Journal: Chemistry - a European journal 
Abstract: A nickel-catalyzed asymmetric oxazole-forming Ugi reaction of C,N-cyclic azomethine imines and isonitriles is disclosed. The reported protocol proceeds smoothly, and gives the corresponding adducts, which contain two important pharmaceutically active ring-systems (tetrahydroquinoline and oxazole rings), in good yields and excellent enantioselectivities by employing an easily accessible chiral diamine as a ligand. This simple and efficient strategy provides easy access to a series of C1-substituted aryl tetrahydroisoquinolines.
URI: http://hdl.handle.net/10397/76359
ISSN: 0947-6539
EISSN: 1521-3765
DOI: 10.1002/chem.201700970
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