Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/76357
Title: Engineering of single magnetic particle carrier for living brain cell imaging : a tunable T-1-/T-2-/Dual-modal contrast agent for magnetic resonance imaging application
Authors: Peng, YK
Lui, CNP
Chen, YW
Chou, SW
Raine, E
Chou, PT
Yung, KKL
Tsang, SCE
Issue Date: 2017
Publisher: American Chemical Society
Source: Chemistry of materials, 2017, v. 29, no. 10, p. 4411-4417 How to cite?
Journal: Chemistry of materials 
Abstract: Despite a variety of T-1-T-2 dual-modal contrast agents (DMCAs) reported for magnetic resonance imaging (MRI), no tuning of local induced magnetic field strength of an DMCA, which is important to modulate the overall T-1 and T-2 responses for imaging delicate cells, tissues, and organs, is yet available. Here, we show that a spatial arrangement of T-1 and T-2 components within a "nano zone" in a single core-shell nanoparticle carrier (i.e., DMCA with core Fe3O4 and MnO clusters in a silica shell) to produce the necessary finetuning effect. It is demonstrated that this particle after the anti-CD133 antibody immobilization allows both T-1 and T-2 imaging at higher resolution for living ependynmal brain cells of rodents with no local damage under a strong MRI magnetic field. This study opens a route to rational engineering of DMCAs for accurate magnetic manipulations in a safe manner.
URI: http://hdl.handle.net/10397/76357
ISSN: 0897-4756
EISSN: 1520-5002
DOI: 10.1021/acs.chemmater.7b00884
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