Please use this identifier to cite or link to this item:
Title: X-ray-activated near-infrared persistent luminescent probe for deep-tissue and renewable in vivo bioimaging
Authors: Xue, ZL
Li, XL
Li, YB
Jiang, MY
Liu, HR
Zeng, SJ
Hao, JH 
Keywords: NIR persistent luminescence
X-ray excitation
In vivo rechargeable bioimaging
X-ray-activated NIR persistent bioimaging
Issue Date: 2017
Publisher: American Chemical Society
Source: ACS applied materials and interfaces, 2017, v. 9, no. 27, p. 22132-22142 How to cite?
Journal: ACS applied materials and interfaces 
Abstract: Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) are considered as new alternative optical probes due to being free of autofluorescence, benefited from the self-sustained emission after excitation and high signal-to-noise ratio. However, the NIR-emitted PLNPs always present a short decay time and require excitation by ultraviolet or visible light with a short penetrable depth, remarkably hindering their applications for in vivo long-term tracking and imaging. Therefore, it is important to develop NIR-emitted PLNPs with in vivo activation nature by new excitation sources with deeper penetrating depths. Here, we propose a new type of X-ray-activated ZnGa2O4:Cr PLNPs (X-PLNPs) with efficient NIR persistent emission and rechargeable activation features, in which both the excitation and emission possess a high penetrable nature in vivo. These X-PLNPs exhibit long-lasting, up to 6 h, NIR emission at 700 nm after the stoppage of the X-ray excitation source. More importantly, the designed X-PLNPs can be readily reactivated by a soft X-ray excitation source with low excitation power (45 kVp, 0.5 rnA) to restore in vivo bioimaging signals even at 20 mm depth. Renewable in vivo whole-body bioimaging was also successfully achieved via intravenous injection/oral administration of X-PLNPs after in situ X-ray activation. This is the first time that NLR-emitted PLNPs have been demonstrated to be recharged by X-ray light for deep-tissue in vivo bioimaging, which paves the way for in vivo renewable bioimaging using PLNPs and makes the PLNPs more competitive in bioimaging area.
ISSN: 1944-8244
EISSN: 1944-8252
DOI: 10.1021/acsami.7b03802
Appears in Collections:Journal/Magazine Article

View full-text via PolyU eLinks SFX Query
Show full item record


Last Week
Last month
Citations as of Dec 5, 2018


Last Week
Last month
Citations as of Dec 5, 2018

Page view(s)

Last Week
Last month
Citations as of Dec 9, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.