Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/76156
Title: Biocompatible polyelectrolyte complex nanoparticles from lactoferrin and pectin as potential vehicles for antioxidative curcumin
Authors: Yan, JK 
Qiu, WY
Wang, YY
Wu, JY 
Keywords: Lactoferrin
Pectin
Polyelectrolyte complex nanoparticles
Curcumin carriers
Water solubility
Controlled release
Antioxidant activity
Issue Date: 2017
Publisher: American Chemical Society
Source: Journal of agricultural and food chemistry, 2017, v. 65, no. 28, p. 5720-5730 How to cite?
Journal: Journal of agricultural and food chemistry 
Abstract: Polyelectrolyte complex nanoparticles (PEC NPs) were fabricated via electrostatic interactions between positively charged heat -denatured lactoferrin (LF) particles and negatively charged pectin. The obtained PEC NPs were then utilized as curcumin carriers. PEC NPs were prepared by mixing 1.0 mg/mL solutions of heat -denatured LF and pectin at a mass ratio of 1:1 (w/w) in the absence of NaCl at pH 4.50. PEC NPs that were prepared under optimized conditions were spherical in shape with a particle size of similar to 208nm and zeta potential of similar to-32 mV. Hydrophobic curcumin was successfully encapsulated into LF/ pectin PEC NPs with high encapsulation efficiency (similar to 85.3%) and loading content (similar to 13.4%). The in vitro controlled release and prominent antioxidant activities of curcumin from LF/pectin PEC NPs were observed. The present work provides a facile and fast method to synthesize nanoscale food-grade delivery systems for the improved water solubility, controlled release, and antioxidant activity of hydrophobic curcumin.
URI: http://hdl.handle.net/10397/76156
ISSN: 0021-8561
EISSN: 1520-5118
DOI: 10.1021/acs.jafc.7b01848
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