Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/76150
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dc.contributor.authorLi, ZYen_US
dc.contributor.authorLiao, CRen_US
dc.contributor.authorChen, DNen_US
dc.contributor.authorSong, Jen_US
dc.contributor.authorJin, Wen_US
dc.contributor.authorPeng, GDen_US
dc.contributor.authorZhu, Fen_US
dc.contributor.authorWang, Yen_US
dc.contributor.authorHe, Jen_US
dc.contributor.authorWang, YPen_US
dc.date.accessioned2018-05-10T02:55:27Z-
dc.date.available2018-05-10T02:55:27Z-
dc.date.issued2017-
dc.identifier.citationOptics express, 2017, v. 25, no. 15, p. 17105-17113en_US
dc.identifier.issn1094-4087-
dc.identifier.urihttp://hdl.handle.net/10397/76150-
dc.description.abstractWe propose and experimentally verify an innovative label-free optical fiber biosensor based on a Mach-Zehnder interferometer for bovine serum albumin (BSA) concentration detection. The proposed fiber biosensor utilized a micro-cavity within a single-mode fiber to induce Mach-Zehnder interference. A remarkable feature of this biosensor is that external media can directly interact with the fiber core signal through microfluidic channels connected to the micro-cavity and sensor surface. The device was fabricated by means of femtosecond laser micromachining and chemical etching. A fiber interferometer of this type exhibits an ultrahigh refractive index sensitivity of -10,055 nm/RIU and a detection limit of 3.5 x 10(-5) RIU. Different concentrations of BSA with an infinitesimally small refractive index difference can be clearly differentiated in situ by the interferential spectra of the structure. Experiments demonstrated the biosensor exhibited a BSA solution concentration sensitivity of -38.9 nm/(mg/mL) and a detection limit of 2.57 x 10(-4) mg/mL, respectively. Moreover, this biosensor is a sub-microliter dose and ultrasensitive at the low concentrations detected in BSA, which make it a promising for biochemical applications such as DNA hybridization, cancer screenings, medicine examination and environmental engineering, etc.en_US
dc.description.sponsorshipDepartment of Electrical Engineeringen_US
dc.language.isoenen_US
dc.publisherOptical Society of Americaen_US
dc.relation.ispartofOptics expressen_US
dc.titleLabel-free detection of bovine serum albumin based on an in-fiber Mach-Zehnder interferometric biosensoren_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage17105-
dc.identifier.epage17113-
dc.identifier.volume25-
dc.identifier.issue15-
dc.identifier.doi10.1364/OE.25.017105-
dc.identifier.isiWOS:000408584400019-
dc.identifier.pmid28789206-
dc.identifier.eissn1094-4087-
dc.identifier.rosgroupid2017006698-
dc.description.ros2017-2018 > Academic research: refereed > Publication in refereed journal-
dc.description.validate201805 bcrc-
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