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Title: Label-free detection of bovine serum albumin based on an in-fiber Mach-Zehnder interferometric biosensor
Authors: Li, ZY
Liao, CR
Chen, DN
Song, J
Jin, W 
Peng, GD
Zhu, F
Wang, Y
He, J
Wang, YP
Issue Date: 2017
Publisher: Optical Society of America
Source: Optics express, 2017, v. 25, no. 15, p. 17105-17113 How to cite?
Journal: Optics express 
Abstract: We propose and experimentally verify an innovative label-free optical fiber biosensor based on a Mach-Zehnder interferometer for bovine serum albumin (BSA) concentration detection. The proposed fiber biosensor utilized a micro-cavity within a single-mode fiber to induce Mach-Zehnder interference. A remarkable feature of this biosensor is that external media can directly interact with the fiber core signal through microfluidic channels connected to the micro-cavity and sensor surface. The device was fabricated by means of femtosecond laser micromachining and chemical etching. A fiber interferometer of this type exhibits an ultrahigh refractive index sensitivity of -10,055 nm/RIU and a detection limit of 3.5 x 10(-5) RIU. Different concentrations of BSA with an infinitesimally small refractive index difference can be clearly differentiated in situ by the interferential spectra of the structure. Experiments demonstrated the biosensor exhibited a BSA solution concentration sensitivity of -38.9 nm/(mg/mL) and a detection limit of 2.57 x 10(-4) mg/mL, respectively. Moreover, this biosensor is a sub-microliter dose and ultrasensitive at the low concentrations detected in BSA, which make it a promising for biochemical applications such as DNA hybridization, cancer screenings, medicine examination and environmental engineering, etc.
ISSN: 1094-4087
EISSN: 1094-4087
DOI: 10.1364/OE.25.017105
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