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Title: Modulated excitation imaging system for intravascular ultrasound
Authors: Qiu, WB
Wang, XY
Chen, Y 
Fu, Q
Su, M
Zhang, LN
Xia, JJ
Dai, JY
Zhang, YN
Zheng, HR
Keywords: High-frequency ultrasound
Intravascular ultrasound (IVUS)
Modulated excitation
Ultrasound imaging
Ultrasound system
Issue Date: 2017
Publisher: Institute of Electrical and Electronics Engineers
Source: IEEE transactions on biomedical engineering, 2017, v. 64, no. 8, p. 1935-1942 How to cite?
Journal: IEEE transactions on biomedical engineering 
Abstract: Advances in methodologies and tools often lead to new insights into cardiovascular diseases. Intravascular ultrasound (IVUS) is a well-established diagnostic method that provides high-resolution images of the vessel wall and atherosclerotic plaques. High-frequency (>50 MHz) ultrasound enables the spatial resolution of IVUS to approach that of optical imaging methods. However, the penetration depth decreases when using higher imaging frequencies due to the greater acoustic attenuation. An imaging method that improves the penetration depth of high-resolution IVUS would, therefore, be of major clinical importance. Modulated excitation imaging is known to allow ultrasound waves to penetrate further. This paper presents an ultrasound system specifically for modulated-excitation-based IVUS imaging. The system incorporates a high-voltage waveform generator and an image processing board that are optimized for IVUS applications. In addition, a miniaturized ultrasound transducer has been constructed using a Pb(Mg1/3Nb2/3)O-3-PbTiO3 single crystal to improve the ultrasound characteristics. The results show that the proposed system was able to provide increases of 86.7% in penetration depth and 9.6 dB in the signal-tonoise ratio for 60 MHz IVUS. In vitro tissue samples were also investigated to demonstrate the performance of the system.
ISSN: 0018-9294
EISSN: 1558-2531
DOI: 10.1109/TBME.2016.2631224
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