Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/75897
DC Field | Value | Language |
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dc.contributor | Department of Biomedical Engineering | - |
dc.contributor | Department of Health Technology and Informatics | - |
dc.contributor | School of Optometry | - |
dc.creator | Xi, LYY | en_US |
dc.creator | Yip, SP | en_US |
dc.creator | Shan, SW | en_US |
dc.creator | Summers-Rada, J | en_US |
dc.creator | Kee, CS | en_US |
dc.date.accessioned | 2018-05-10T02:54:53Z | - |
dc.date.available | 2018-05-10T02:54:53Z | - |
dc.identifier.issn | 2045-2322 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/75897 | - |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en_US |
dc.rights | © The Author(s) 2017 | en_US |
dc.rights | The following publication Xi, L.Y., Yip, S.P., Shan, S.W. et al. Region-specific differential corneal and scleral mRNA expressions of MMP2, TIMP2, and TGFB2 in highly myopic-astigmatic chicks. Sci Rep 7, 11423 (2017) is available at https://dx.doi.org/10.1038/s41598-017-08765-6 | en_US |
dc.title | Region-specific differential corneal and scleral mRNA expressions of MMP2, TIMP2, and TGFB2 in highly myopic-astigmatic chicks | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 7 | en_US |
dc.identifier.doi | 10.1038/s41598-017-08765-6 | en_US |
dcterms.abstract | Myopia and astigmatism, two common refractive errors frequently co-exist, are affecting vision at all working distances in the affected populations worldwide. Eyeballs having these refractive errors are known to exhibit abnormal eye shape at the anterior and posterior eye segments, but whether the outer coats of these abnormal eyeballs, cornea anteriorly and sclera posteriorly, are regulated by region-specific molecular mechanism remains unclear. Here we presented the changes in mRNA expression levels of three genes (MMP2, TIMP2, and TGFB2), all known to participate in extracellular matrix organization, at five regions of the cornea and sclera in chickens developing high myopia and astigmatism induced by form deprivation. We found that, compared to normal chicks, the highly myopic-astigmatic chicks had significantly higher expression of all three genes in the superior sclera (Mann-Whitney tests, all p <= 0.05), as well as higher TIMP2 expression in the central cornea and nasal sclera (Mann-Whitney tests, both p <= 0.05). Strikingly, the superior scleral region stood out as showing the strongest and most widespread correlations between mRNA expression and biometry parameters including axial and astigmatic components (r = + 0.52 similar to + 0.85, all p < 0.05). These results imply that local molecular mechanism may manipulate the eye shape remodeling across the globe during refractive-error development. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Scientific reports, 12 2017, v. 7, no. , 11423, p. 1-10 | en_US |
dcterms.isPartOf | Scientific reports | en_US |
dcterms.issued | 2017 | - |
dc.identifier.isi | WOS:000410297900137 | - |
dc.identifier.scopus | 2-s2.0-85029319072 | - |
dc.identifier.pmid | 28900109 | - |
dc.identifier.eissn | 2045-2322 | en_US |
dc.identifier.artn | 11423 | en_US |
dc.identifier.rosgroupid | 2017003357 | - |
dc.description.ros | 2017-2018 > Academic research: refereed > Publication in refereed journal | - |
dc.description.validate | 201805 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Xi_Region-specific_Corneal_Scleral.pdf | 2.48 MB | Adobe PDF | View/Open |
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