Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/75888
Title: Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation
Authors: Jin, K
Po, KHL 
Wang, SX
Reuven, JA
Wai, CN
Lau, HT
Chan, TH
Chen, S
Li, XC
Keywords: Teixobactin analogues
SAR study
Ser/Thr ligation
Issue Date: 2017
Publisher: Pergamon Press
Source: Bioorganic & medicinal chemistry, 2017, v. 25, no. 18, p. 4990-4995 How to cite?
Journal: Bioorganic & medicinal chemistry 
Abstract: Convergent Ser/Thr ligation has been used to prepare a series of teixobactin analogues (28 in total) to establish a structure-activity relationship of teixobactin. anti-bacterial evaluations of these synthetic analogues have revealed the critical amino acid residues and the sites tolerable of modifications. These studies will shed lights on the further development of teixobactin analogues with improved antibacterial activities.
URI: http://hdl.handle.net/10397/75888
ISSN: 0968-0896
EISSN: 1464-3391
DOI: 10.1016/j.bmc.2017.04.039
Appears in Collections:Journal/Magazine Article

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