Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/75860
Title: Maslinic acid promotes autophagy by disrupting the interaction between Bcl2 and Beclin1 in rat pheochromocytoma PC12 cells
Authors: Dong, XL 
Zhang, JX
Zhou, ZL
Ye, ZN
Chen, JH
Yuan, JF
Cao, FJ
Wang, XB
Liu, WC 
Yu, WX 
Li, XH 
Keywords: Maslinic acid
Autophagy
Regulation
Beclin1
Bcl2
Issue Date: 2017
Publisher: Impact Journals LLC
Source: Oncotarget, 2017, v. 8, no. 43, p. 74527-74538 How to cite?
Journal: Oncotarget 
Abstract: Maslinic acid (2 alpha, 3 beta-dihydroxyolean-12-en-28-oic acid, MA) was isolated from natural plants and showed anti-cancer activity in rat Pheochromocytoma PC12 cells in our previous studies. We now discover that MA disrupts the interaction between Bcl2 and autophagy scaffold protein Beclin1 in the above cell line, leading to the up-regulation of autophagy. We investigated the effect of MA on the interaction between Bcl2 and Beclin1 by biochemical and biophysical methods in combination with autophagy characterization in the above cell line. Our results suggest that MA may serve as an autophagy activator by directly blocking the Bcl2-Beclin1 interaction to release free Beclin1 required for the recruitment of autophagy positive regulators, implying MA may exert its anti-cancer activity by regulating autophagy.
URI: http://hdl.handle.net/10397/75860
ISSN: 1949-2553
DOI: 10.18632/oncotarget.20210
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