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Title: New application of tiplaxtinin as an effective FtsZ-targeting chemotype for an antimicrobial study
Authors: Sun, N 
Zheng, YY
Du, RL 
Cai, SY
Zhang, K
So, LY 
Cheung, KC 
Zhuo, C
Lu, YJ
Wong, KY 
Issue Date: 2017
Publisher: Royal Society of Chemistry
Source: Medchemcomm, 2017, v. 8, no. 10, p. 1909-1913 How to cite?
Journal: Medchemcomm 
Abstract: The filamenting temperature-sensitive mutant Z (FtsZ) protein is generally recognized as a promising antimicrobial drug target. In the present study, a small organic molecule (tiplaxtinin) was identified for the first time as an excellent cell division inhibitor by using a cell-based screening approach from a library with 250 compounds. Tiplaxtinin possesses potent antibacterial activity against Gram-positive pathogens. Both in vitro and in vivo results reveal that the compound is able to disrupt dynamic assembly of FtsZ and Z-ring formation effectively through the mechanism of stimulating FtsZ polymerization and impairing GTPase activity.
ISSN: 2040-2503
EISSN: 2040-2511
DOI: 10.1039/c7md00387k
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