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Title: Construction and characterization of nanosized curdlan sulfate/chitosan polyelectrolyte complex toward drug release of zidovudine
Authors: Yan, JK 
Wang, YY
Qiu, WY
Wu, JY 
Keywords: Curdlan sulfate
Polyelectrolyte complex
Drug delivery
Issue Date: 2017
Publisher: Elsevier
Source: Carbohydrate polymers, 2017, v. 174, p. 209-216 How to cite?
Journal: Carbohydrate polymers 
Abstract: In this study, as-synthesized curdlan sulfate (CRDS) with a flexible random coil chain was selected as a polyanion to construct nanosized polyelectrolyte complexes (PECs) with a polycation, chitosan (CS), via electrostatic interactions. Nanosized PECs were formed simply by mixing CRDS (0.5 mg/mL) and CS (0.5 mg/mL) at a mass ratio of 2:1 at pH 3.5. The CRDS/CS PECs exhibited a spherical morphology with a Z-average diameter of around 180 nm and a zeta potential value of about -38 mV. Subsequently, zidovudine (AZT) as a model antiviral drug was successfully encapsulated into the nanosized PECs with a favorable drug loading efficiency. The AZT-loaded PECs presented a controlled and pH-dependent AZT release profile. These findings suggest that the CRDS/CS PECs constructed in the present study can be developed as potential nanocarriers for drug delivery applications.
ISSN: 0144-8617
EISSN: 1879-1344
DOI: 10.1016/j.carbpol.2017.06.082
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