Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/7565
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorZhang, Y-
dc.creatorLi, Q-
dc.creatorLi, X-
dc.creatorWan, HY-
dc.creatorWong, MS-
dc.date.accessioned2015-06-23T09:08:43Z-
dc.date.available2015-06-23T09:08:43Z-
dc.identifier.issn0007-1145-
dc.identifier.urihttp://hdl.handle.net/10397/7565-
dc.language.isoenen_US
dc.publisherCambridge University Pressen_US
dc.subjectBone resorptionen_US
dc.subjectErythrina variegata L.en_US
dc.subjectOsteoporosisen_US
dc.subjectOvariectomised ratsen_US
dc.titleErythrina variegata extract exerts osteoprotective effects by suppression of the process of bone resorptionen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage965-
dc.identifier.epage971-
dc.identifier.volume104-
dc.identifier.issue7-
dc.identifier.doi10.1017/S0007114510001789-
dcterms.abstractOur previous study showed that Erythrina variegata L. (EV) inhibited bone loss and improved bone properties in ovariectomised rats. The purpose of the present study is to investigate the potential mechanism involved in mediating the osteoprotective actions of EV. Female Sprague-Dawley rats were fed a phyto-oestrogen-free diet and subjected to either ovariectomy or a sham operation. Ovariectomised rats were treated with genistein (40mg/kg) as well as low (200mg/kg), medium (500mg/kg) or high (1000mg/kg) doses of EV extract. Bone properties and mRNA expressions were evaluated by micro-computed tomography and quantitative RT-PCR, respectively. Osteoclast differentiation in RAW 2647 cells was studied by tartrate-resistant acid phosphatase (TRAP) staining. High doses of EV could decrease urinary Ca and P excretion, maintain serum Ca and P level, and exert beneficial effects on the micro-structure and morphology of trabecular bone and cortical bone in ovariectomised rats. EV suppressed the up-regulation of cathepsin K mRNA and the down-regulation of osteoprotegrin mRNA in the tibia of ovariectomised rats. TRAP-positive cell numbers were significantly decreased in receptor activator of nuclear factor-B ligand (RANKL)-induced RAW 2647 cells when co-cultured with EV extracts. The present study indicated that the protective effects of EV on bone properties in ovariectomised rats are likely to be mediated by its inhibitory actions on the process of bone resorption via the suppression of osteoclast differentiation and maturation.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationBritish journal of nutrition, 2010, v. 104, no. 7, p. 965-971-
dcterms.isPartOfBritish journal of nutrition-
dcterms.issued2010-
dc.identifier.isiWOS:000284012600006-
dc.identifier.scopus2-s2.0-77957921074-
dc.identifier.pmid20487580-
dc.identifier.eissn1475-2662-
dc.identifier.rosgroupidr54348-
dc.description.ros2010-2011 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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