Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/75523
Title: Locally translated mTOR controls axonal local translation in nerve injury
Authors: Terenzio, M
Koley, S
Samra, N
Rishal, I
Zhao, Q 
Sahoo, PK
Urisman, A
Marvaldi, L
Oses-Prieto, JA
Forester, C
Gomes, C
Kalinski, AL
Di Pizio, A
Doron-Mandel, E
Perry, RBT
Koppel, I
Twiss, JL
Burlingame, AL
Fainzilber, M
Issue Date: 2018
Publisher: American Association for the Advancement of Science
Source: Science, 2018, v. 359, no. 6382, p. 1416-1421 How to cite?
Journal: Science 
Abstract: How is protein synthesis initiated locally in neurons? We found that mTOR (mechanistic target of rapamycin) was activated and then up-regulated in injured axons, owing to local translation of mTOR messenger RNA (mRNA). This mRNA was transported into axons by the cell size-regulating RNA-binding protein nucleolin. Furthermore, mTOR controlled local translation in injured axons. This included regulation of its own translation and that of retrograde injury signaling molecules such as importin b1 and STAT3 (signal transducer and activator of transcription 3). Deletion of the mTOR 3′ untranslated region (3′UTR) in mice reduced mTOR in axons and decreased local translation after nerve injury. Both pharmacological inhibition of mTOR in axons and deletion of the mTOR 3′UTR decreased proprioceptive neuronal survival after nerve injury. Thus, mRNA localization enables spatiotemporal control of mTOR pathways regulating local translation and long-range intracellular signaling.
URI: http://hdl.handle.net/10397/75523
ISSN: 0036-8075
EISSN: 1095-9203
DOI: 10.1126/science.aan1053
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