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Title: Silk fibroin/polyethylene glycol nanofibrous membranes loaded with curcumin
Authors: Liu, Q
Zhou, S
Zhao, Z
Wu, T
Wang, R
Xu, S
Liu, L
Xie, R
Zheng, Z
Li, G
Xie, M 
Wang, X
Issue Date: 2017
Source: Thermal science, 2017, v. 21, no. 4, p. 1587-1594
Abstract: In order to improve the stability, utilization ratio and anti-tumor effect of curcumin drug, a set of curcumin-loaded nanofiber membranes with drug releasing property were fabricated using silk fibroin and polyethylene glycol. Various curcumin- loaded silk fibroin nanofiber membranes with different components and drug loading percentages were prepared using electrospinning technology. The morphology structure, mechanical properties, secondary structure, drug release property in vitro, and their interaction effects of the curcumin-loaded silk fibroin nanofiber membranes were examined. The result of in-vitro drug release experiment showed that the curcumin can be released stably up to 350 hours, the drug releasing speed increased with the decrease of the diameter of the fibers. The stability and utilization ratio of curcumin was improved after loading with curcumin- loaded silk fibroin nanofiber membranes. In conclusion, it can be used as a control drug release system alternately in the future.
Keywords: Curcumin
Nanofibrous membranes
Polyethylene glycol
Silk fibroin
Publisher: Serbian Society of Heat Transfer Engineers
Journal: Thermal science 
ISSN: 0354-9836
DOI: 10.2298/TSCI160708039L
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