Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/74577
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dc.contributorSchool of Optometry-
dc.creatorHon, Y-
dc.creatorChen, GZ-
dc.creatorLu, SH-
dc.creatorLam, DCC-
dc.creatorLam, AKC-
dc.date.accessioned2018-03-29T07:17:14Z-
dc.date.available2018-03-29T07:17:14Z-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10397/74577-
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.rights© The Author(s) 2017en_US
dc.titleIn vivo measurement of regional corneal tangent modulusen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage2-
dc.identifier.volume7-
dc.identifier.issue1-
dc.identifier.doi10.1038/s41598-017-14750-w-
dcterms.abstractCurrently available clinical devices are unable to measure corneal biomechanics other than at the central region. Corneal stiffness (S), thickness, and radius of curvature was measured at the central cornea (primary fixation) and 3 mm from the temporal limbus (primary and nasal fixations). The corneal tangent modulus (E) of 25 healthy subjects was calculated from these data. After confirming normality, repeated measures analysis of variance (RMANOVA) revealed significant difference in S (F(2, 48) = 21.36, p < 0.001) at different corneal regions and direction of fixations. E also varied significantly at different corneal regions and direction of fixations (RMANOVA: F(2, 48) = 23.06, p < 0.001). A higher S and a lower E were observed at the temporal region compared with the corneal centre. Nasal fixation further increased S and E values compared with primary fixation. Due to the specific arrangement of corneal collagen fibrils, heterogeneity of corneal biomechanical properties is expected. In future clinical practice, localized corneal biomechanical alternation and measurement might assist corneal disease detection and post-surgery management. In addition, practitioners should be aware of the fixation effect on corneal biomechanical measurement.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationScientific reports, 2017, v. 7, no. 1, 14974, p. 2-
dcterms.isPartOfScientific reports-
dcterms.issued2017-
dc.identifier.scopus2-s2.0-85032830045-
dc.identifier.eissn2045-2322-
dc.identifier.artn14974-
dc.identifier.rosgroupid2017004658-
dc.description.ros2017-2018 > Academic research: refereed > Publication in refereed journal-
dc.description.validate201802 bcrc-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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