Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/7456
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Benzie, IFF | - |
dc.date.accessioned | 2014-12-19T04:17:27Z | - |
dc.date.available | 2014-12-19T04:17:27Z | - |
dc.identifier.issn | 0029-6651 | - |
dc.identifier.uri | http://hdl.handle.net/10397/7456 | - |
dc.language.iso | en | en_US |
dc.subject | Antioxidants | en_US |
dc.subject | Ascorbic acid | en_US |
dc.subject | Functional marker | en_US |
dc.subject | Micronutrient status | en_US |
dc.subject | Vitamin C | en_US |
dc.title | Vitamin C : prospective functional markers for defining optimal nutritional status | en_US |
dc.type | Conference Paper | en_US |
dc.identifier.spage | 469 | - |
dc.identifier.epage | 476 | - |
dc.identifier.volume | 58 | - |
dc.identifier.issue | 2 | - |
dc.identifier.doi | 10.1017/S0029665199000610 | - |
dcterms.abstract | Most species of plants and animals synthesize ascorbic acid, but human subjects cannot, making vitamin C an essential component of our diet. Relationships between vitamin C intake and status, and between status and health are not yet clear. There is evidence, however, that higher intake of vitamin C is associated with lower risk of disease, supporting the concept that optimal intake is needed for optimal vitamin C status, and that both factors are required for optimal health. Vitamin C has low toxicity in healthy subjects, but a clear definition of optimal status and the dietary intake required to meet and maintain this status is needed before a change in the current recommended intake can be considered. Available evidence suggests that intake of 200 mg vitamin C/d saturates tissues and maintains fasting plasma levels above the proposed threshold (50 μmol/l) for minimum risk of CHD. However, the issue of whether or not these levels produce 'optimal vitamin C status' awaits the clear and accepted definition of the term. This definition in turn awaits the development of reliable functional markers capable of assessing the effects of varying levels of vitamin C nutriture. In the present paper the relationship between intake and body stores of vitamin C and the role of vitamin C in human health are reviewed briefly. The requirements of a reliable functional marker of human vitamin C status are defined, three classes of functional markers (molecular, biochemical and physiological) are described, and possible candidate markers are examined. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Proceedings of the Nutrition Society, 1999, v. 58, no. 2, p. 469-476 | - |
dcterms.issued | 1999 | - |
dc.identifier.isi | WOS:000081952800035 | - |
dc.identifier.scopus | 2-s2.0-0032770056 | - |
dc.identifier.pmid | 10466192 | - |
dc.relation.ispartofbook | Proceedings of the Nutrition Society | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Conference Paper |
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File | Description | Size | Format | |
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Benzie_Vitamin_C.pdf | 514.69 kB | Adobe PDF | View/Open |
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