Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/74557
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorSham, TT-
dc.creatorZhang, H-
dc.creatorMok, DKW-
dc.creatorChan, SW-
dc.creatorWu, J-
dc.creatorTang, S-
dc.creatorChan, CO-
dc.date.accessioned2018-03-29T07:17:11Z-
dc.date.available2018-03-29T07:17:11Z-
dc.identifier.issn2076-3921en_US
dc.identifier.urihttp://hdl.handle.net/10397/74557-
dc.language.isoenen_US
dc.publisherMolecular Diversity Preservation International (MDPI)en_US
dc.rights© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.rightsThe following publication Sham, T.T.; Zhang, H.; Mok, D.K.W.; Chan, S.W.; Wu, J.; Tang, S.; Chan, C.O. Chemical Analysis of Astragali Complanati Semen and Its Hypocholesterolemic Effect Using Serum Metabolomics Based on Gas Chromatography-Mass Spectrometry. Antioxidants 2017, 6, 57, 1-16 is available at https://dx.doi.org/10.3390/antiox6030057en_US
dc.subjectAstragali Complanati Semenen_US
dc.subjectHypercholesterolemiaen_US
dc.subjectMass spectrometryen_US
dc.subjectSerum metabolomicsen_US
dc.titleChemical analysis of astragali Complanati semen and its hypocholesterolemic effect using serum metabolomics based on gas chromatography-mass spectrometryen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1en_US
dc.identifier.epage16en_US
dc.identifier.volume6en_US
dc.identifier.issue3en_US
dc.identifier.doi10.3390/antiox6030057en_US
dcterms.abstractThe hypocholesterolemic protective effect of the dried seed of Astragalus complanatus (ACS) was investigated in rats fed with normal diet, high cholesterol diet (HCD), and HCD plus 70% ethanol extract of ACS (600 mg/kg/day) by oral gavage for four weeks. ACS extract was tested to be rich in antioxidants, which may be contributed to its high content of phenolic compounds. Consumption of ACS remarkably suppressed the elevated total cholesterol (p < 0.01) and LDL-C (p < 0.001) induced by HCD. Chemical constituents of ACS extract were analyzed by ultra-performance liquid chromatography coupled with electrospray ionization orbitrap mass spectrometry and the results showed that the ACS extract mainly consisted of phenolic compounds including flavonoids and flavonoid glycosides. In addition, based on the serum fatty acid profiles, elucidated using gas chromatography-mass spectrometry, free and esterified fatty acids including docosapentaenoic acid, adrenic acid, dihomo-γ-linolenic acid and arachidonic acid were regulated in ACS treatment group. Western blot results further indicated the protein expression of peroxisome proliferator-activated receptor alpha (PPARα) (p < 0.05) in liver was upregulated in ACS treatment group. To conclude, our results clearly demonstrated that ACS provides beneficial effect on lowering HCD associated detrimental change.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationAntioxidants, Sep. 2017, v. 6, no. 3, 57, p. 2-
dcterms.isPartOfAntioxidants-
dcterms.issued2017-
dc.identifier.scopus2-s2.0-85026298250-
dc.identifier.artn57en_US
dc.identifier.rosgroupid2017005357-
dc.description.ros2017-2018 > Academic research: refereed > Publication in refereed journalen_US
dc.description.validate201802 bcrcen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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