Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/74557
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Sham, TT | - |
dc.creator | Zhang, H | - |
dc.creator | Mok, DKW | - |
dc.creator | Chan, SW | - |
dc.creator | Wu, J | - |
dc.creator | Tang, S | - |
dc.creator | Chan, CO | - |
dc.date.accessioned | 2018-03-29T07:17:11Z | - |
dc.date.available | 2018-03-29T07:17:11Z | - |
dc.identifier.issn | 2076-3921 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/74557 | - |
dc.language.iso | en | en_US |
dc.publisher | Molecular Diversity Preservation International (MDPI) | en_US |
dc.rights | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Sham, T.T.; Zhang, H.; Mok, D.K.W.; Chan, S.W.; Wu, J.; Tang, S.; Chan, C.O. Chemical Analysis of Astragali Complanati Semen and Its Hypocholesterolemic Effect Using Serum Metabolomics Based on Gas Chromatography-Mass Spectrometry. Antioxidants 2017, 6, 57, 1-16 is available at https://dx.doi.org/10.3390/antiox6030057 | en_US |
dc.subject | Astragali Complanati Semen | en_US |
dc.subject | Hypercholesterolemia | en_US |
dc.subject | Mass spectrometry | en_US |
dc.subject | Serum metabolomics | en_US |
dc.title | Chemical analysis of astragali Complanati semen and its hypocholesterolemic effect using serum metabolomics based on gas chromatography-mass spectrometry | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 16 | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.doi | 10.3390/antiox6030057 | en_US |
dcterms.abstract | The hypocholesterolemic protective effect of the dried seed of Astragalus complanatus (ACS) was investigated in rats fed with normal diet, high cholesterol diet (HCD), and HCD plus 70% ethanol extract of ACS (600 mg/kg/day) by oral gavage for four weeks. ACS extract was tested to be rich in antioxidants, which may be contributed to its high content of phenolic compounds. Consumption of ACS remarkably suppressed the elevated total cholesterol (p < 0.01) and LDL-C (p < 0.001) induced by HCD. Chemical constituents of ACS extract were analyzed by ultra-performance liquid chromatography coupled with electrospray ionization orbitrap mass spectrometry and the results showed that the ACS extract mainly consisted of phenolic compounds including flavonoids and flavonoid glycosides. In addition, based on the serum fatty acid profiles, elucidated using gas chromatography-mass spectrometry, free and esterified fatty acids including docosapentaenoic acid, adrenic acid, dihomo-γ-linolenic acid and arachidonic acid were regulated in ACS treatment group. Western blot results further indicated the protein expression of peroxisome proliferator-activated receptor alpha (PPARα) (p < 0.05) in liver was upregulated in ACS treatment group. To conclude, our results clearly demonstrated that ACS provides beneficial effect on lowering HCD associated detrimental change. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Antioxidants, Sep. 2017, v. 6, no. 3, 57, p. 2 | - |
dcterms.isPartOf | Antioxidants | - |
dcterms.issued | 2017 | - |
dc.identifier.scopus | 2-s2.0-85026298250 | - |
dc.identifier.artn | 57 | en_US |
dc.identifier.rosgroupid | 2017005357 | - |
dc.description.ros | 2017-2018 > Academic research: refereed > Publication in refereed journal | en_US |
dc.description.validate | 201802 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Sham_Chemical_Astragali_Complanati.pdf | 3.07 MB | Adobe PDF | View/Open |
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