Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/74535
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dc.contributorDepartment of Biomedical Engineeringen_US
dc.creatorLiu, Xen_US
dc.creatorGao, Pen_US
dc.creatorDu, Jen_US
dc.creatorZhao, Xen_US
dc.creatorWong, KKYen_US
dc.date.accessioned2018-03-29T07:17:04Z-
dc.date.available2018-03-29T07:17:04Z-
dc.identifier.issn0022-3468en_US
dc.identifier.urihttp://hdl.handle.net/10397/74535-
dc.language.isoenen_US
dc.publisherW.B. Saundersen_US
dc.rights© 2017 Elsevier Inc. All rights reserved.en_US
dc.rights© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.rightsThe following publication Liu, X., Gao, P., Du, J., Zhao, X., & Wong, K. K. (2017). Long-term anti-inflammatory efficacy in intestinal anastomosis in mice using silver nanoparticle-coated suture. Journal of Pediatric Surgery, 52(12), 2083-2087 is available at https://doi.org/10.1016/j.jpedsurg.2017.08.026en_US
dc.subjectAnti-inflammatoryen_US
dc.subjectIntestinal anastomosisen_US
dc.subjectRemodelingen_US
dc.subjectSilver nanoparticlesen_US
dc.subjectSuturesen_US
dc.titleLong-term anti-inflammatory efficacy in intestinal anastomosis in mice using silver nanoparticle-coated sutureen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage2083en_US
dc.identifier.epage2087en_US
dc.identifier.volume52en_US
dc.identifier.issue12en_US
dc.identifier.doi10.1016/j.jpedsurg.2017.08.026en_US
dcterms.abstractBackground: In our previous study, we coated silver nanoparticles (AgNPs) onto the surface of absorbable braided suture using layer-by-layer deposition and demonstrated significant anti-inflammatory property during the early phase of intestinal anastomosis healing in mice. The present study aimed to further investigate the long-term anti-inflammatory efficacy. Methods: AgNP-coated suture, antibiotic coated suture, and normal suture were respectively used for single layered, interrupted intestinal anastomosis. The anastomotic segments in each group were harvested on day 14, day 21, and day 28 postoperation and investigated for the degree of inflammation by cell infiltration and expression of cytokines as well as collagen deposition. Results: When compared with the control groups, the AgNP-coated suture group showed better histological appearance in the intestinal anastomotic segments at each time point. Immunohistochemistry staining and quantitative evaluation further indicated less macrophage infiltration and decreased production of IL-6, IL-10, and TNF-α (p <. 0.05). Masson staining showed normal collagen deposition and remodeling at intestinal anastomotic tissue in the AgNP-coated suture group. Conclusion: Our study shows that AgNP-coated suture provides better long-term anti-inflammatory efficacy and ideal tissue remodeling in intestinal anastomosis. Despite these findings, clinical trials are still needed for evaluation before medical application.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationJournal of pediatric surgery, Dec. 2017, v. 52, no. 12, p. 2083-2087en_US
dcterms.isPartOfJournal of pediatric surgeryen_US
dcterms.issued2017-12-
dc.identifier.scopus2-s2.0-85029830231-
dc.identifier.rosgroupid2017004118-
dc.description.ros2017-2018 > Academic research: refereed > Publication in refereed journalen_US
dc.description.validate201802 bcrcen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumbera0596-n55, BME-0178en_US
dc.identifier.SubFormID499-
dc.description.fundingSourceSelf-fundeden_US
dc.description.pubStatusPublisheden_US
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