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Title: Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection
Authors: Cheung, KT 
Sze, DMY
Chan, KH
Leung, PHM 
Keywords: Caspase-4
Dengue virus
Issue Date: 2017
Publisher: Elsevier
Source: Immunobiology, 2017, p. 2 How to cite?
Journal: Immunobiology 
Abstract: Caspase-4 physically interacts with caspase-1 and is believed to be a proinflammatory caspase that can induce the inflammatory form of programmed cell death (pyroptosis) and the release of mature interleukin (IL)-1β. However, the function of caspase-4 in dengue virus infection is not yet fully understood. We examined the function of caspase-4 in IL-1β production and pyroptosis during dengue virus serotype-2 (DENV-2) infection in human macrophages. In this study, DENV-2 infection increased IL-1β protein level with activated caspase-4 activity. Using primary macrophages, we observed that caspase-4 induces activation of caspase-1 and secretion of IL-1β in response to DENV-2 infection, without the need for secondary signals to stimulate the assembly of the inflammasome. These findings indicate that the regulation of caspase-1 activity by capsase-4 could represent a unique mechanism. Our data suggest that caspase-4 is upstream of caspase-1 in the pathway that regulates pyroptosis and IL-1β synthesis in macrophages during DENV-2 infection.
ISSN: 0171-2985
DOI: 10.1016/j.imbio.2017.10.044
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