Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/74482
DC Field | Value | Language |
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dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Guo, S | - |
dc.creator | Guo, T | - |
dc.creator | Cheng, N | - |
dc.creator | Liu, Q | - |
dc.creator | Zhang, Y | - |
dc.creator | Bai, L | - |
dc.creator | Zhang, L | - |
dc.creator | Cao, W | - |
dc.creator | Ho, CT | - |
dc.creator | Bai, N | - |
dc.date.accessioned | 2018-03-29T07:16:55Z | - |
dc.date.available | 2018-03-29T07:16:55Z | - |
dc.identifier.issn | 2225-4110 | - |
dc.identifier.uri | http://hdl.handle.net/10397/74482 | - |
dc.language.iso | en | en_US |
dc.publisher | National Taiwan University | en_US |
dc.rights | © 2016, Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. | | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_US |
dc.rights | The following publication Guo, S., Guo, T., Cheng, N., Liu, Q., Zhang, Y., Bai, L., ... & Bai, N. (2017). Hepatoprotective standardized etoh–water extract from the seeds of fraxinus rhynchophylla hance. Journal of traditional and complementary medicine, 7(2), 158-164 is available at https://doi.org/10.1016/j.jtcme.2016.05.001 | en_US |
dc.subject | ALT and AST | en_US |
dc.subject | CCl4-induced hepatic injury mice | en_US |
dc.subject | Fraxinus rhynchophylla Hance | en_US |
dc.subject | Hepatoprotective | en_US |
dc.subject | Secoiridoid glucosides | en_US |
dc.title | Hepatoprotective standardized EtOH–water extract from the seeds of Fraxinus rhynchophylla Hance | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 158 | - |
dc.identifier.epage | 164 | - |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 2 | - |
dc.identifier.doi | 10.1016/j.jtcme.2016.05.001 | - |
dcterms.abstract | Fraxinus rhynchophylla Hance (Oleaceae), its stem barks are known as Cortex fraxini (秦皮 qín pí) listed in Chinese Pharmacopoeia. Phytochemical study has indicated that methanol extracts from Qinpi has protective effect on acute liver injury. The present study investigates the hepatoprotective activity of EtOH–water extract from the seeds of F. rhynchophylla Hance against carbon tetrachloride-induced liver injury in mice. The EtOH–water extract significantly alleviated liver damage as indicated by the decreased levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the malondialdehyde (MDA) content, and increased the levels of superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GSH-Px), and reduced the pathological tissue injury induced by CCl4. Quantitative analysis of seven major constituents (1–7) in EtOH–water extract (EWE) was developed by high performance liquid chromatography-diode-array detector (HPLC-DAD). The current research indicates that the EWE from the seeds of F. rhynchophylla Hance decreased liver index, inhibited the increase of serum aminotransferase induced by CCl4, and decreased hepatic MDA content, SOD and GSH-Px activities. These results suggested that the pretreatment with EWE protected mice against CCl4-induced liver injuries. Based on the results, the EtOH–water extract from the seeds of F. rhynchophylla Hance is efficacious for prevention and treatment of CCl4-induced hepatic injury in mice. Secoiridoid and tyrosol glucosides might be the active ingredients responsible for the biological and pharmacological activities of hepatoprotection. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Journal of traditional and complementary medicine, 2017, v. 7, no. 2, p. 158-164 | - |
dcterms.isPartOf | Journal of traditional and complementary medicine | - |
dcterms.issued | 2017 | - |
dc.identifier.scopus | 2-s2.0-84973878943 | - |
dc.description.validate | 201802 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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Guo_Hepatoprotective_Standardized_Etoh.pdf | 1 MB | Adobe PDF | View/Open |
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