Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/70708
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | en_US |
dc.creator | Wong, KC | en_US |
dc.creator | Cao, SS | en_US |
dc.creator | Dong, XL | en_US |
dc.creator | Law, MC | en_US |
dc.creator | Chan, TH | en_US |
dc.creator | Wong, MS | en_US |
dc.date.accessioned | 2017-12-28T06:17:53Z | - |
dc.date.available | 2017-12-28T06:17:53Z | - |
dc.identifier.issn | 2072-6643 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/70708 | - |
dc.language.iso | en | en_US |
dc.publisher | Molecular Diversity Preservation International (MDPI) | en_US |
dc.rights | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Wong, K. C., Cao, S. S., Dong, X. L., Law, M. C., Chan, T. H., & Wong, M. S. (2017). (-)-Epiafzelechin protects against ovariectomy-induced bone loss in adult mice and modulate osteoblastic and osteoclastic functions in vitro. Nutrients, 9(5), 530, 1-14 is available at https://dx.doi.org/10.3390/nu9050530 | en_US |
dc.subject | (-)-epiafzelechin | en_US |
dc.subject | Flavan-3-ol | en_US |
dc.subject | Ovariectomised | en_US |
dc.subject | Osteogenesis | en_US |
dc.subject | Osteoclastogenesis | en_US |
dc.subject | Trabecular bone | en_US |
dc.title | (-)-Epiafzelechin protects against ovariectomy-induced bone loss in adult mice and modulate osteoblastic and osteoclastic functions in vitro | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 9 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.doi | 10.3390/nu9050530 | en_US |
dcterms.abstract | The present study was designed to characterize the bone protective effects of (-)-epiafzelechin (EAF), a flavan-3-ol, in mature ovariectomized mice model and its ability to stimulate osteoblastic activity and inhibit osteoclastic activity. Mature C57BL/6 mice (three to four months old) were either ovariectomised (OVX) or sham-operated and subjected to treatment (vehicle, 17 beta-oestradiol (E2, 200 mu g/kg/day) or EAF ( 500 mu g/kg/day) orally for six weeks. EAF and E2 significantly reduced urinary calcium (Ca) excretion, serum osteocalcin (OCN), and urinary deoxy-pyridinoline (DPD); increased bone mineral density (BMD); and improved micro-architectural properties in OVX mice. EAF significantly increased cell viability, alkaline phosphatise (ALP) activity, and collagen content, as well as runt-related transcriptional factor 2 (Runx2) mRNA expression in murine osteoblastic MC3T3-E1 cells. In addition, EAF significantly reduced the viability of osteoclast precursor murine leukemia monocyte RAW264.7 cells and tartrate-resistant acid phosphatase (TRAP) activities in mature osteoclastic RAW 264.7 cells. EAF is a bioactive flavan-3-ol that protects estrogen deficiency-induced bone loss in OVX mice and exerts direct modulating effects in bone cells in vitro. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Nutrients, May 2017, v. 9, no. 5, 530, p. 1-14 | en_US |
dcterms.isPartOf | Nutrients | en_US |
dcterms.issued | 2017-05 | - |
dc.identifier.isi | WOS:000402054500107 | - |
dc.identifier.scopus | 2-s2.0-85019951892 | - |
dc.identifier.ros | 2016002267 | - |
dc.identifier.artn | 530 | en_US |
dc.identifier.rosgroupid | 2016002220 | - |
dc.description.ros | 2016-2017 > Academic research: refereed > Publication in refereed journal | en_US |
dc.description.validate | 201712 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a0691-n01, a1375 | - |
dc.identifier.SubFormID | 941, 44729 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Others: General Research Fund (GRF) (PolyU 5632/09M and PolyU 5003/05P);Research Studentship of the Hong Kong Polytechnic University;Shenzhen Basic Research Program (JCYJ20140819153305697, JCYJ20140819153305696, JCYJ20151030164008764);National Natural Science Foundation of China (81220108028);National Major Scientific and Program of Introducing Talents of Discipline to Universities (B13038);PolyU 5632/09M | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Wong_(-)-Epiafzelechin_Protects_Ovariectomy-induced.pdf | 1.44 MB | Adobe PDF | View/Open |
Page views
97
Last Week
0
0
Last month
Citations as of Apr 21, 2024
Downloads
45
Citations as of Apr 21, 2024
SCOPUSTM
Citations
16
Last Week
0
0
Last month
Citations as of Apr 19, 2024
WEB OF SCIENCETM
Citations
13
Last Week
0
0
Last month
Citations as of Apr 25, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.