Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/7010
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Zhang, G | - |
dc.creator | Tsang, CM | - |
dc.creator | Deng, W | - |
dc.creator | Yip, YL | - |
dc.creator | Lui, VWY | - |
dc.creator | Wong, SCC | - |
dc.creator | Cheung, ALM | - |
dc.creator | Hau, PM | - |
dc.creator | Zeng, M | - |
dc.creator | Lung, ML | - |
dc.creator | Chen, H | - |
dc.creator | Lo, KW | - |
dc.creator | Takada, K | - |
dc.creator | Tsai, SW | - |
dc.date.accessioned | 2014-12-11T08:26:56Z | - |
dc.date.available | 2014-12-11T08:26:56Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/7010 | - |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | © 2013 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.title | Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 13 | - |
dc.identifier.volume | 8 | - |
dc.identifier.issue | 5 | - |
dc.identifier.doi | 10.1371/journal.pone.0062284 | - |
dcterms.abstract | Nasopharyngeal carcinoma (NPC) is etiologically associated with Epstein-Barr virus (EBV) infection. However, the exact role of EBV in NPC pathogenesis remains elusive. Activation of signal transducer and activator of transcription 3 (STAT3) is common in human cancers including NPC and plays an important role in the pathogenesis and progression of human cancers. Interleukin-6 (IL-6), a major inflammatory cytokine, is a potent activator of STAT3. In this study, we report that EBV-infected immortalized nasopharyngeal epithelial (NPE) cells often acquire an enhanced response to IL-6-induced STAT3 activation to promote their growth and invasive properties. Interestingly, this enhanced IL-6/STAT3 response was mediated by overexpression of IL-6 receptor (IL-6R). Furthermore, IL-6R overexpression enhanced IL-6-induced STAT3 activation in uninfected immortalized NPE cells in vitro, and promoted growth and tumorigenicity of EBV-positive NPC cell line (C666-1) in vivo. Moreover, it is shown for the first time that IL-6R was overexpressed in clinical specimens of NPC. IL-6 expression could also be strongly detected in the stromal cells of NPC and a higher circulating level of IL-6 was found in the sera of advance-staged NPC patients compared to the control subjects. Therefore, IL-6R overexpression, coupled with enhanced IL-6/STAT3 signaling may facilitate the malignant transformation of EBV-infected premalignant NPE cells into cancer cells, and enhance malignant properties of NPC cells. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | PLoS one, 1 May 2013, v. 8, no. 5, e62284, p.1-13 | - |
dcterms.isPartOf | PLoS one | - |
dcterms.issued | 2013-05-01 | - |
dc.identifier.isi | WOS:000319167000038 | - |
dc.identifier.scopus | 2-s2.0-84877040826 | - |
dc.identifier.pmid | 23658720 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.rosgroupid | r62362 | - |
dc.description.ros | 2012-2013 > Academic research: refereed > Publication in refereed journal | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Zhang_IL-6_IL-6R_EBV.pdf | 5.7 MB | Adobe PDF | View/Open |
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