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Title: Application of tensorial description of the fibrous molecules geometrical arrangement in vascular tissues and cells
Authors: Huang, W
Mak, YW
Chen, PCY
Issue Date: 2010
Source: IFMBE Proceedings, 2010, v. 31, p. 875-878
Abstract: Vascular cells and extracellular matrix in blood vessel wall are exposed to dynamic stretching and shearing due to blood pressure and blood flow and always adapting to hemodynamics changes. It is unclear how remodeling of bio-molecules affects the mechanical properties of tissues and cells in health and in disease. An accurate mapping of the geometry of individual molecules and the geometrical structure of the aggregation of the molecules is essential in understand molecular biomechanics and the derivation of constitutive equations describing their mechanical properties. Our goal is to express the mechanics of the molecules in a constitutive equation of the vascular tissues and cells, which relates the stress, strain, molecular configuration, and history by the biomechanical and continuum approach. The first step to accomplish our goal is to obtain the geometric information of the molecules. A molecular configuration tensor Pgij
Keywords: Blood vessel
Fibrous protein
α-smooth muscle-actin
Publisher: springer
Journal: IFMBE Proceedings 
ISBN: 978-3-642-14514-8
ISSN: 1867-5662
DOI: 10.1007/978-3-642-14515-5_223
Description: International Federation for Medical and Biological Engineering Proceedings ,Singapore, 1-6 August 2010
Appears in Collections:Conference Paper

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