Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/68794
Title: Red marrow dosimetry for radiolabeled antibodies that bind to marrow,bone, or blood components
Authors: Sgouros, G
Stabin, M
Erdi, Y
Akabani, G
Kwok, C 
Brill, AB
Wessels, B
Issue Date: 2000
Publisher: American Association of Physicists in Medicine
Source: Medical physics, 2000, v. 27, no. 9, p. 2150-2164 How to cite?
Journal: Medical physics 
Abstract: Hematologic toxicity limits the radioactivity that may be administered for radiolabeled antibody therapy. This work examines approaches for obtaining biodistribution data and performing dosimetry when the administered antibody is known to bind to a cellular component of blood, bone, or marrow. Marrow dosimetry in this case is more difficult because the kinetics of antibody clearance from the blood cannot be related to the marrow. Several approaches for obtaining antibody kinetics in the marrow are examined and evaluated. The absorbed fractions and S factors that should be used in performing marrow dosimetry are also examined and the effect of including greater anatomical detail is considered. The radiobiology of the red marrow is briefly reviewed. Recommendations for performing marrow dosimetry when the antibody binds to the marrow are provided.
URI: http://hdl.handle.net/10397/68794
ISSN: 0094-2405
EISSN: 2473-4209
DOI: 10.1118/1.1288393
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

51
Last Week
0
Last month
Citations as of Nov 19, 2017

WEB OF SCIENCETM
Citations

49
Last Week
0
Last month
Citations as of Nov 19, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.