Apatite/keratin composite scaffold and preparation method thereof

Abstract

The invention discloses an apatite/keratin composite scaffold and a preparation method thereof. The preparation method includes: precipitating apatite and keratin in aqueous solution to obtain precipitation of an apatite and keratin composition, flushing, filtering and freezing to dry the precipitation so as to form the apatite/keratin composite scaffold. The apatite/keratin composite scaffold has excellent biological property, such as biological computability, cellular affinity, biodegradability and morphological stability. Owning to the microstructure of the apatite/keratin composite scaffold, good attachment and multiplication of osteoblasts on the scaffold can be improved, guiding for regeneration of bone tissues is facilitated, and ultimate biodegradation is formed along with generation of new bone tissue. The preparation method is easy, and the apatite/keratin composite scaffold is prepared from raw materials in wide source, and is a novel artificial bone material with excellent bone induction performance and wide application prospect. 本发明公开了一种磷灰石/角蛋白复合支架及其制备方法。该方法包括：通过在水溶液中共沉淀磷灰石和角蛋白的步骤得到磷灰石与角蛋白复合物的沉淀，然后经过冲洗、过滤并冻干该沉淀，形成磷灰石/角蛋白复合支架。根据本发明的方法形成的磷灰石/角蛋白复合支架具有显著的生物性，比如生物相容性、细胞亲和力、生物降解性和形态稳定性；并且该复合支架的微观结构可以提高成骨细胞在支架上进行良好附着和增殖，有助于引导骨组织的再生，并随着新的骨组织的生成最终降解。本发明中的制备方法简单，所用原料来源广泛，所制备的磷灰石/角蛋白复合支架是一种具有优异的骨诱导性能和广泛应用前景的新型人工骨材料。