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Title: Site-directed pegylation of arginases and use thereof as anti-cancer and anti-viral agents
Other Titles: 精氨酸酶的定向位点聚乙二醇化及其作为抗癌和抗病毒试剂的用途
Authors: Leung, TYC 
Lo, TWH 
Issue Date: 22-Apr-2015
Publisher: 中华人民共和国国家知识产权局
Source: 中国专利 ZL 201080023256.4 How to cite?
Abstract: Mono-pegylated arginase conjugate and method producing thereof. The mono-pegylated arginase is homogeneous in molecular weight and shows therapeutic effect for treating cancers and viral infections. The method of producing such arginase conjugate has a main step of genetically modifying the gene encoding an arginase so that the PEG moiety can attach to the enzyme at a predetermined, specific intended site. This is achieved by removing the PEG attaching amino acid residues at undesirable sites while keeping (or adding, if necessary) the one at the desirable site of the enzyme. Two exemplary mono-pegylated arginase conjugates so produced are human arginase I (HAI) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys45 of the enzyme and Bacillus caldovelox arginase (BCA) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys161 of the enzyme.
Rights: 专利权人: The Hong Kong Polytechnic University.
Appears in Collections:Patent

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