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Title: siRNA recombinant slow virus for inhibiting human hephaestin gene expression and application
Other Titles: 抑制人膜铁转运蛋白辅助蛋白基因表达的siRNA重组慢病毒及应用
Authors: Qian, ZM 
Ge, XH 
Ke, Y 
Issue Date: 12-Jun-2013
Publisher: 中华人民共和国国家知识产权局
Source: 中国专利 ZL 200910107003.4 How to cite?
Abstract: The invention provides small-interference RNA for inhibiting human hephaestin (HEPH) gene expression. The small-interference RNA is reversely complemented with human HEPH mRNA, and the length of the small-interference RNA is 19 to 27bp. The invention further discloses a DNA sequence for coding the corresponding shRNA of the small-interference RNA and recombinant slow virus capable of expressing the shRNA. The small-interference RNA, the DNA for coding the shRNA and the recombinant slow virus can effectively inhibit in vivo human HEPH expression, inhibit the release and metabolism of iron and adjust the serum iron level in vivo so as to fulfill the purpose of treating iron metabolism related diseases.
Rights: 专利权人: The Hong Kong Polytechnic University.
Appears in Collections:Patent

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