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Title: Flavonoid dimers and methods of making and using such
Other Titles: 类黄酮二聚物及其制备方法和使用方法
Authors: Chow, MCL 
Chan, TH 
Issue Date: 29-Aug-2012
Publisher: 中华人民共和国国家知识产权局
Source: 中国专利 ZL 200780018290.0 How to cite?
Abstract: Multidrug resistance (MDR) is a major problem in cancer chemotherapy. The best characterized resistance mechanism is the one mediated by the over- expression of drug efflux transporters, permeability-glycoprotein (P-gp), which pump a variety of anticancer drugs out of the cells, resulting in lowered intracellular drug accumulation. A series of flavonoid dimers are developed in this invention, which are linked together by linker groups of various lengths. These flavonoid dimers are found to be efficient P-gp modulators that increase cytotoxicity of anticancer drugs in vitro and dramatically enhance their intracellular drug accumulation. It is found that the flavonoid dimers of this invention are also useful in reducing drug resistance in treating parasitic diseases.
Rights: 专利权人: The Hong Kong Polytechnic University.
Appears in Collections:Patent

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