Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/68493
Title: Chiral recognition and determination of enantiomeric excess by mass spectrometry : a review
Authors: Yu, XY 
Yao, ZP 
Keywords: Mass spectrometry
Chiral recognition
Enantiomeric excess (ee)
Ion mobility
Issue Date: 2017
Publisher: Elsevier
Source: Analytica chimica acta, 2017, v. 968, p. 1-20 How to cite?
Journal: Analytica chimica acta 
Abstract: Chiral analysis is of great importance to fundamental and applied research in chemical, biological and pharmaceutical sciences. Due to the superiority of mass spectrometry (MS) over other analytical methods in terms of speed, specificity and sensitivity, chiral analysis by MS has attracted much interest in recent years. Chiral analysis by MS typically involves introduction of a chiral selector to form diastereomers with analyte enantiomers, and comparison of the behaviors of diastereomers in MS. Chiral differentiation can be achieved by comparing the relative abundances of diastereomers, the thermodynamic or kinetic constants of ion-molecule reactions of diastereomers in the gas phase, the dissociation of diastereomers in MS/MS, or the mobility of diastereomers in ion mobility mass spectrometry. In this review, chiral recognition and determination of enantiomeric excess by these chiral MS methods were summarized, and the prospects of chiral analysis by MS were discussed.
URI: http://hdl.handle.net/10397/68493
ISSN: 0003-2670
EISSN: 1873-4324
DOI: 10.1016/j.aca.2017.03.021
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