Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/68453
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Chan, TH | - |
dc.creator | Chow, LMC | - |
dc.date.accessioned | 2017-08-22T05:55:05Z | - |
dc.date.available | 2017-08-22T05:55:05Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/68453 | - |
dc.language.iso | en | en_US |
dc.rights | Assignee: The Hong Kong Polytechnic Univeristy | en_US |
dc.rights | Assignee: McGill University. | en_US |
dc.title | Flavonoid dimers and methods of making and using such | en_US |
dc.type | Patent | en_US |
dc.description.otherinformation | US8710097; US8710097 B2; US8710097B2; US8,710,097; US 8,710,097 B2; 8710097; Appl. No. 12/301,504 | en_US |
dcterms.abstract | Multidrug resistance (MDR) is a major problem in cancer chemotherapy. The best characterized resistance mechanism is the one mediated by the over-expression of drug efflux transporters, permeability-glycoprotein (P-gp), which pump a variety of anticancer drugs out of the cells, resulting in lowered intracellular drug accumulation. A series of flavonoid dimers are developed in this invention, which are linked together by linker groups of various lengths. These flavonoid dimers are found to be efficient P-gp modulators that increase cytotoxicity of anticancer drugs in vitro and dramatically enhance their intracellular drug accumulation. It is found that the flavonoid dimers of this invention is also useful in reducing drug resistance in treating parasitic diseases. | - |
dcterms.bibliographicCitation | US Patent 8,710,097 B2. Washington, DC: US Patent and Trademark Office, 2014. | - |
dcterms.issued | 2014-04-29 | - |
dc.description.country | US | - |
dc.identifier.rosgroupid | r71660 | - |
dc.description.ros | 2013-2014 > Other Outputs > Patents granted | - |
dc.description.oa | Version of Record | en_US |
Appears in Collections: | Patent |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
us8710097b2.pdf | 2.58 MB | Adobe PDF | View/Open |
Page views
89
Last Week
0
0
Last month
Citations as of Apr 21, 2024
Downloads
31
Citations as of Apr 21, 2024
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.