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Title: Lack of Fc gamma receptor IIIA promotes rather than suppresses humoral and cellular immune responses after mucosal or parenteral immunization with antigen and adjuvants
Authors: Sun, JB
Holmgren, J
Cragg, MS
Zou, X 
Issue Date: Apr-2017
Publisher: John Wiley & Sons
Source: Scandinavian journal of immunology, Apr. 2017, v. 85, no. 4, p. 264-271 How to cite?
Journal: Scandinavian journal of immunology 
Abstract: The Fcc receptor IIIA (Fc gamma RIIIA) has traditionally been known as a positive regulator of immune responses. Consistent with this, mice deficient in Fc gamma RIIIA are protected from various inflammation-associated pathologies including several autoimmune diseases. In contrast to this accepted dogma, we show here that mice lacking Fc gamma RIIIA developed increased rather than reduced both humoral and cellular immune responses to mucosal (sublingual) immunization with ovalbumin (OVA) given together with the strong mucosal adjuvant cholera toxin as well as to parenteral (subcutaneous) immunization with OVA in complete Freund's adjuvant. After either route of immunization, in comparison with concomitantly immunized wild-type mice, Fc gamma RIIIA(-/)-mice had increased serum anti-OVA IgG (IgG1 but not IgG2) antibody responses as well as augmented cellular responses that included memory B cells and effector T cells. The increments in immune responses in Fc gamma RIIIA(-/)-mice were similar to those seen in Fc gamma RIIIA(-/)-mice. Furthermore, OVA-pulsed Fc gamma RIIIA(-/)-DCs, similar to OVA-specific Fc gamma RIIIA(-/-), had enhanced capacity to activate OVA-specific OT-II T cells, which was even further pronounced when DCs were pulsed with IgG1-complexed OVA. Our data support an inhibitory-regulatory role of Fc gamma RIIIA on vaccine/ adjuvant-induced immune responses and demonstrate that lack of Fc gamma RIIIA can promote rather than suppress both humoral and cellular immune responses.
ISSN: 0300-9475
EISSN: 1365-3083
DOI: 10.1111/sji.12528
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