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Title: Synthesis of chiral-bridged atropisomeric monophosphine ligands with tunable dihedral angles and their applications in asymmetric Suzuki-Miyaura coupling reactions
Authors: Xia, W
Li, Y
Zhou, Z
Chen, H
Liang, H
Yu, S
He, X
Zhang, Y
Pang, J
Zhou, Z 
Qiu, L
Keywords: Asymmetric catalysis
Diastereoselective synthesis
Heterocyclic biaryls
Monophosphine ligands
Quinoline derivatives
Suzuki coupling
Issue Date: 2017
Publisher: Wiley-VCH
Source: Advanced synthesis & catalysis, 2017, v. 359, no. 10, p. 1656-1662 How to cite?
Journal: Advanced synthesis & catalysis 
Abstract: Precise chiral recognition was firstly realized in the construction of diastereomeric biaryl monophosphines by means of the substrate-directed asymmetric annulation reactions. A series of new chiral-bridged atropisomeric biphenyl monophosphine ligands with tunable dihedral angles was accordingly synthesized successfully without a resolution step being needed. Using these ligands, different kinds of axially chiral 1,1′-biaryl-2-phosphonates including the first reported quinolyl biaryl phosphonates were prepared in 42-97% yields with up to 96% ee via palladium-catalyzed asymmetric Suzuki coupling reactions.
ISSN: 1615-4150
EISSN: 1615-4169
DOI: 10.1002/adsc.201700020
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