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Title: In vitro drug release and percutaneous behavior of poloxamer-based hydrogel formulation containing traditional Chinese medicine
Authors: Wang, WY
Hui, PCL 
Wat, E
Ng, FSF 
Kan, CW 
Wang, XW
Wong, ECW
Hu, HW
Chan, B
Lau, CBS
Leung, PC
Keywords: Thermosensitive hydrogel therapy
Herbal medicine
Release kinetic
Percutaneous behavior
Issue Date: 2016
Publisher: Elsevier
Source: Colloids and surfaces B : biointerfaces, 1 Dec. 2016, v. 148, p. 526-532 How to cite?
Journal: Colloids and surfaces B : biointerfaces 
Abstract: For the treatment of atopic dermatitis (AD), we have developed a transdermal functionalized textile therapy based on thermosensitive poloxamer 407 (P407) hydrogel containing a traditional Chinese herbal medicine. This study aims to investigate the effects of various formulation variables of P407/carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel on the release of Cortex Moutan (CM) extract. Concentrations of P407 and CMCs showed significant influence on the release due to alteration of bulk viscosity of the system. An increase in pH values of release medium was found to appreciably impede the release of polar drug (CM) due to ionization. Elevated temperatures were also shown to facilitate the drug release. Moreover, the diffusional release behavior of CM from P407/CMCs composite hydrogel was found to follow the first-order kinetic model. Additionally, transdermal studies showed that permeability of the drug through the skin can be enhanced with addition of CMCs in the hydrogel formulation.
ISSN: 0927-7765
DOI: 10.1016/j.colsurfb.2016.09.036
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