Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/66453
Title: Gold nanoparticle-capped mesoporous silica-based H2O2-responsive controlled release system for Alzheimer's disease treatment
Authors: Yang, LC
Yin, TT
Liu, YA
Sun, J
Zhou, YH
Liu, J
Keywords: Alzheimer's disease
Metal ions
Amyloid-beta
Controlled release system
Mesoporous silica nanoparticle
Issue Date: 2016
Publisher: Elsevier
Source: Acta biomaterialia, Dec. 2016, v. 46, p. 177-190 How to cite?
Journal: Acta biomaterialia 
Abstract: Metal ions promote Alzheimer's disease (AD) pathogenesis by accelerating amyloid-beta (A beta) aggregation and inducing formation of neurotoxic reactive oxygen species (ROS) such as hydrogen peroxide (H2O2). Although metal chelators can block these effects, their therapeutic potential is marred by their inability to cross the blood-brain barrier (BBB) and by their non-specific interactions with metal ions necessary for normal cellular processes, which could result in adverse side effects. To overcome these limitations, we created a novel gold nanoparticle-capped mesoporous silica (MSN-AuNPs) based H2O2-responsive controlled release system for targeted delivery of the metal chelator CQ. In this system, CQ is released only upon exposure to conditions in which H2O2 levels are high, such as those in A beta plaques. The conjugation of AuNPs on the surface of MSN did not affect their ability to cross the BBB. The AuNPs also help in decrease the A beta self-assembly, due to this, MSN-CQ-AuNPs were more efficient than MSN-CQ in inhibiting Cu2+-induced A beta(40) aggregation. Furthermore, MSN-CQ-AuNPs reduced the cell membrane disruption, microtubular defects and ROS-mediated apoptosis induced by A beta(40)-Cu2+ complexes. The high BBB permeability, efficient anti-A beta aggregation, and good biocompatibility of MSN-CQ-AuNPs, together with the specific conditions necessary for its release of CQ, demonstrate its potential for future biomedical applications. Statement of Significance Due to the low ability to cross the blood-brain barrier (BBB) and non-specific interactions with metal ions necessary for normal cellular processes of metal chelator or A beta inhibitors, we created a novel gold nanoparticle-capped mesoporous silica (MSN-AuNPs)-based H2O2-responsive controlled release system for targeted delivery of the metal chelator CQ and AuNP5 (A beta inhibitor). In this system, CQ and AuNPs are released only upon exposure to conditions in which H2O2 levels are high, such as those in All plaques. The AuNPs on the surface of MSN also help in decrease the A beta self-assembly, due to this, MSN-CQ-AuNPs were more efficient than MSN-CQ in inhibiting Cu2+-induced A beta(40) aggregation. Furthermore, MSN-CQ-AuNPs reduced the cell membrane disruption, microtubular defects and ROS-mediated apoptosis induced by A beta(40)-Cu2+ complexes. Our data suggest that this controlled release system may have widespread application in the field of medicine for Alzheimer's disease.
URI: http://hdl.handle.net/10397/66453
EISSN: 1742-7061
DOI: 10.1016/j.actbio.2016.09.010
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