Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/66109
Title: Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme (Review)
Authors: Gang, W
Wang, JJ
Fu, XL
Rui, G
To, Tony
Keywords: Glioblastoma multiforme
Glucose metabolism
HIF-1α
Mitochondria
Oncogenes
Signaling pathways
Issue Date: 2017
Publisher: Spandidos Publications
Source: Oncology reports, 2017, v. 37, no. 2, p. 657-670 How to cite?
Journal: Oncology reports 
Abstract: Cell metabolism can be reprogrammed by tissue hypoxia leading to cell transformation and glioblastoma multiforme (GBM) progression. In response to hypoxia, GBM cells are able to express a transcription factor called hypoxia inducible factor-1 (HIF-1). HIF-1 belongs to a family of heterodimeric proteins that includes HIF-1α and HIF-1β subunits. HIF-1α has been reported to play a pivotal role in GBM development and progression. In the present review, we discuss the role of HIF-1α in glucose uptake, cancer proliferation, cell mobility and chemoresistance in GBM. Evidence from previous studies indicates that HIF-1α regulates angiogenesis, metabolic and transcriptional signaling pathways. Examples of such are the EGFR, PI3K/Akt and MAPK/ERK pathways. It affects cell migration and invasion by regulating glucose metabolism and growth in GBM cells. The present review focuses on the strategies through which to target HIF-1α and the related downstream genes highlighting their regulatory roles in angiogenesis, apoptosis, migration and glucose metabolism for the development of future GBM therapeutics. Combined treatment with inhibitors of HIF-1α and glycolysis may enhance antitumor effects in clinical settings.
URI: http://hdl.handle.net/10397/66109
ISSN: 1021-335X
EISSN: 1791-2431
DOI: 10.3892/or.2016.5309
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

1
Last Week
0
Last month
Citations as of Jan 20, 2018

WEB OF SCIENCETM
Citations

2
Last Week
0
Last month
Citations as of Jan 20, 2018

Page view(s)

34
Last Week
4
Last month
Citations as of Jan 21, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.