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Title: Jagged 2 silencing inhibits motility and invasiveness of colorectal cancer cell lines
Authors: He, W
Chan, CML
Wong, SCC 
Ho, WS
Chan, AKC
Chan, ASK
Chan, ATC
Keywords: Colorectal cancer
Jagged 2
Issue Date: 2016
Publisher: Spandidos Publications
Source: Oncology letters, 2016, v. 12, no. 6, p. 5193-5198 How to cite?
Journal: Oncology letters 
Abstract: Although the Notch pathway has been reported to be activated in colorectal cancer (CRC), limited information is available regarding the expression and role of its ligand, Jagged 2 (JAG2), in CRC. Using immunohistochemistry, the present study demonstrated that JAG2 protein expression may be detected in up to 95% of CRC cases and is 3-fold upregulated in tumor cells compared to surrounding normal tissues. This finding suggests that JAG2 may have a role in the tumorigenicity of CRC. To further investigate the cellular functions of JAG2 expression in CRC, two different small interfering RNAs (siRNAs) were used to downregulate JAG2 expression in CRC cell lines (HCT116, DLD-1 and HT-29). The results indicated that JAG2 knockdown inhibits the motility and invasiveness of CRC cell lines without significantly affecting cell proliferation. These findings implicate JAG2 in promoting aggressiveness of CRC, and lay the foundation for its future development as a therapeutic target for the treatment of CRC.
ISSN: 1792-1074
EISSN: 1792-1082
DOI: 10.3892/ol.2016.5321
Appears in Collections:Journal/Magazine Article

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