Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/65310
Title: Catalytic direct C2-alkenylation of oxazoles at parts per million levels of palladium/PhMezole-Phos complex
Authors: Fu, WC
Wu, Y
So, CM
Wong, SM
Lei, A
Kwong, FY 
Issue Date: 2016
Publisher: American Chemical Society
Source: Organic letters, 2016, v. 18, no. 20, p. 5300-5303 How to cite?
Journal: Organic letters 
Abstract: General direct C2-alkenylation of oxazoles is reported using alkenyl tosylates at parts per million levels of palladium catalyst. From a series of ligands screened, PhMezole-Phos emerged as the promising ligand candidate to facilitate this reaction. Significantly, the method is scalable and exhibits excellent substrate tolerance. Highly sterically hindered substrates and small vinyl tosylate can be coupled successfully. Moreover, our method enables a rapid diversification of oxazole-based C^N ligands which can be readily derived into new group 9 organometallic compounds.
URI: http://hdl.handle.net/10397/65310
ISSN: 1523-7060
EISSN: 1523-7052
DOI: 10.1021/acs.orglett.6b02619
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