Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/65277
Title: Inhibitory masking controls the threshold sensitivity of retinal ganglion cells
Authors: Pan, F 
Toychiev, A
Zhang, Y
Atlasz, T
Ramakrishnan, H
Roy, K
Völgyi, B
Akopian, A
Bloomfield, SA
Keywords: Adaptation
Gaba
Inhibition
Retinal ganglion cell
Vision
Issue Date: 15-Nov-2016
Publisher: Wiley-Blackwell
Source: The journal of physiology, 2016, v. 594, no. 22, p. 6679-6699 How to cite?
Journal: The journal of physiology 
Abstract: Retinal ganglion cells (RGCs) in dark-adapted retinas show a range of threshold sensitivities spanning ∼3 log units of illuminance. Here, we show that the different threshold sensitivities of RGCs reflect an inhibitory mechanism that masks inputs from certain rod pathways. The masking inhibition is subserved by GABAC receptors, probably on bipolar cell axon terminals. The GABAergic masking inhibition appears independent of dopaminergic circuitry that has been shown also to affect RGC sensitivity. The results indicate a novel mechanism whereby inhibition controls the sensitivity of different cohorts of RGCs. This can limit and thereby ensure that appropriate signals are carried centrally in scotopic conditions when sensitivity rather than acuity is crucial.
URI: http://hdl.handle.net/10397/65277
ISSN: 0022-3751
EISSN: 1469-7793
DOI: 10.1113/JP272267
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