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Title: Comparison of antibiotic susceptibilities of Staphylococcus aureus and S. intermedius isolates from dog owners and their dogs
Authors: Boost, M
Lai, S
Ko, D
O'Donoghue, M 
Issue Date: 2007
Publisher: Elsevier
Source: Clinical microbiology and infection, 2007, v. 13, suppl. 1, O26, p. s6-s7 (Oral Presentation) (Abstracts) How to cite?
Journal: Clinical microbiology and infection 
Abstract: Objectives: Antibiotic resistance in veterinary isolates has been reported to be higher than in human isolates due to frequent empirical use, and there are concerns about transfer of resistance between staphylococcal species. S. intermedius is the more common colonising species in dogs, but S. aureus , including MRSA, may also be present. Case reports suggest there can be cross-infection between companion animals and man. Increasing concern about MRSA in the community has led to recommendations for surveillance of antibiotic resistance in isolates from companion animals. This study compared antibiotic resistance in isolates of S. aureus and S. intermedius from dogs and their owners.
Methods: A cross-sectional study of owners and their dogs was performed using a convenience sample of 800 pairs recruited at six veterinary practices. Nasal swabs were collected from both owner and dog, and held at 4ºC in transport medium until culture within 8h of collection. Subjects completed a questionnaire providing demographic information of owner and dog, and stating if the dog had received antibiotics within the last 3 months. Swabs were inoculated onto blood agar and mannitol salt agar and placed in 5% salt meat broth for enrichment. S. aureus or S. intermedius were identified by means of coagulase, VP, polymyxin susceptibility, and trehalose fermentation. Several colonies of each isolate were tested for susceptibility to methicillin. Antibiotic susceptibilities were determined by disc diffusion and interpreted using CLSI guidelines.
Results: S. aureus : 168 owners (25%) and 64 dogs (8.5%) were colonised. 16 owners and their dogs were concurrently colonised. 6 dogs (1.3%) and 4 humans (0.5%) were colonised with MRSA. Resistance to oxacillin, clindamycin, gentamicin, tetracycline and fusidic acid was significantly higher in dog isolates. S. intermedius : 64 dogs (7.9%) and 8 owners (1.1%) carried S. intermedius . Four colonised owners had colonised dogs. Methicillin resistance was not detected. Resistance to chloramphenicol, clindamycin, tetracycline, and cotrimoxazole was higher in dog isolates. Resistance to fluoroquinolones and gentamicin was only displayed by dog isolates.
Conclusions: Methicillin resistance was found only in S. aureus ,but resistance to other antibiotics was higher in S. intermedius . Dog isolates were more resistant than human for both species. Veterinary use of antibiotics may increase resistance and the risk of transmission of resistant strains.
Description: 17th European Congress of Clinical Microbiology and Infectious Diseases, and 25th International Congress of Chemotherapy, Munich, Germany, 31 Mar - 3 Apr 2007
ISSN: 1198-743X
EISSN: 1469-0691
DOI: 10.1111/j.1469-0691.2007.01732.x
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