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Title: NanoString, a novel digital color-coded barcode technology : current and future applications in molecular diagnostics
Authors: Tsang, HF
Xue, VW
Koh, SP
Chiu, YM
Wong, SCC 
Keywords: NanoString technologies
NanoString Technologies nCounter Analysis System
Digital color-coded barcode technology
Molecular barcodes
Issue Date: 2017
Publisher: Future Drugs Ltd
Source: Expert review of molecular diagnostics, 2017, v. 17, no. 1, p. 95-103 How to cite?
Journal: Expert review of molecular diagnostics 
Abstract: Introduction: Formalin-fixed, paraffin-embedded (FFPE) tissue sample is a gold mine of resources for molecular diagnosis and retrospective clinical studies. Although molecular technologies have expanded the range of mutations identified in FFPE samples, the applications of existing technologies are limited by the low nucleic acids yield and poor extraction quality. As a result, the routine clinical applications of molecular diagnosis using FFPE samples has been associated with many practical challenges. NanoString technologies utilize a novel digital color-coded barcode technology based on direct multiplexed measurement of gene expression and offer high levels of precision and sensitivity. Each color-coded barcode is attached to a single target-specific probe corresponding to a single gene which can be individually counted without amplification. Therefore, NanoString is especially useful for measuring gene expression in degraded clinical specimens.Areas covered: This article describes the applications of NanoString technologies in molecular diagnostics and challenges associated with its applications and the future development.Expert commentary: Although NanoString technology is still in the early stages of clinical use, it is expected that NanoString-based cancer expression panels would play more important roles in the future in classifying cancer patients and in predicting the response to therapy for better personal therapeutic care.
ISSN: 1473-7159
EISSN: 1744-8352
DOI: 10.1080/14737159.2017.1268533
Appears in Collections:Journal/Magazine Article

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