Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/63810
Title: Comparison of the enteric mucosal immunomodulatory activity of combinations of Coptis chinensis Franch. Rhizomes and Evodia rutaecarpa (Juss.) Benth. Fruits in mice with dextran sulphate sodium-induced ulcerative colitis
Authors: Luo, YY
Zhao, HY
Liu, ZL
Ju, DH
He, XJ
Xiao, C
Zhong, GY
Chen, SL
Yang, DJ
Chan, ASC
Lu, AP
Keywords: Ranunculaceae
Coptis chinensis Franch
Rutaceae
Evodia rutaecarpa (Juss.) Benth
Ulcerative colitis
Mice
Issue Date: 2010
Publisher: Georg Thieme Verlag
Source: Planta medica, 2010, v. 76, no. 8, p. 766-772 How to cite?
Journal: Planta medica 
Abstract: ombinations of crude rhizomes of Coptis chinensis Franch., Ranunculaceae, and fruits of Evodia rutaecarpa (Juss.) Benth., Rutaceae, at a ratio of 6 : 1 (formula A) and 1 : 6 (formula B) were extracted with boiling water, and their modulatory activity on enteric mucosal immune responses in mice with dextran sulphate sodium-induced ulcerative colitis was investigated. The results showed that both formulas could reduce the severity of inflammation in the colon. Formula A at a low dose can decrease myeloperoxidase (MPO) activity, and formula B was inactive. Both formulas did not affect the percentages of CD4+ and CD8+ T cells in the periphery, but they evoked an increase of CD8+ T cells among the enteric intraepithelial lymphocytes. Formula B at a low dose could increase both CD4+ and CD8+ cells, and formula A at a high dose could only increase CD8+ T cells among the Peyer's patch lymphocytes (p < 0.05). Both formulas did not affect the percentages of CD4+ and CD8+ T cells among the lamina propria lymphocytes, but decreased the serum concentration of IL-1β (p < 0.05 at a low dose of formula A) and enhanced the level of IL-10 in serum (p < 0.05 at a low dose formula B). We conclude that both formulas have a similar modulating effect on enteric mucosal immune responses, the major difference being that formula A could decrease the level of IL-1 β, while formula B could increase the IL-10 dose in serum.
URI: http://hdl.handle.net/10397/63810
ISSN: 0032-0943
DOI: 10.1055/s-0029-1240701
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