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Title: Chemical components and tyrosinase inhibitors from the twigs of artocarpus heterophyllus
Authors: Zheng, ZP
Chen, SB
Wang, SY
Wang, XC
Cheng, KW
Wu, JJ
Yang, DJ
Wang, MF
Keywords: Artocarpus heterophyllus
Chemical constituents
Phenolic compounds
Tyrosinase inhibitors
Issue Date: 2009
Publisher: American Chemical Society
Source: Journal of agricultural and food chemistry, 2009, v. 57, no. 15, p. 6649-6655 How to cite?
Journal: Journal of agricultural and food chemistry 
Abstract: An HPLC method was developed and validated to compare the chemical profiles and tyrosinase inhibitors in the woods, twigs, roots, and leaves of Artocarpus heterophyllus. Five active tyrosinase inhibitors including dihydromorin, steppogenin, norartocarpetin, artocarpanone, and artocarpesin were used as marker compounds in this HPLC method. It was discovered that the chemical profiles of A. heterophyllus twigs and woods are quite different. Systematic chromatographic methods were further applied to purify the chemicals in the twigs of A. heterophyllus. Four new phenolic compounds, including one isoprenylated 2-arylbenzofuran derivative, artoheterophyllin A (1), and three isoprenylated flavonoids, artoheterophyllin B (2), artoheterophyllin C (3), and artoheterophyllin D (4), together with 16 known compounds, were isolated from the ethanol extract of the twigs of A. heterophyllus. The structures of compounds 1−4 were elucidated by spectroscopic analysis. However, the four new compounds did not show significant inhibitory activities against mushroom tyrosinase compared to kojic acid. It was found that similar compounds, such as norartocarpetin and artocarpesin in the twigs and woods of A. heterophyllus, contributed to their tyrosinase inhibitory activity.
ISSN: 0021-8561
DOI: 10.1021/jf9014685
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