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Title: Acoustic characterization of nano gas vesicles
Authors: Yang, Y
Qiu, Z
Liu, C
Huang, Y
Dai, JY 
Sun, L 
Keywords: Acoustic characterization
Nano gas vesicle
Ultrasound contrast agent
Molecular imaging
Issue Date: 2015
Publisher: Institute of Electrical and Electronics Engineers
Source: 2015 IEEE International Ultrasonics Symposium Proceedings, Taipei International Convention Center (TICC), Taipei, Taiwan, October 21, 2015-October 24, 2015, p. 1-4 How to cite?
Abstract: Due to the lack of a proper contrast agent, the scope of molecular ultrasound imaging is restricted within blood vessels. Recently reported biogenic nano gas vesicle (NGV), 400nm by 100nm rod shape nano-bubbles encapsulated by a bilayer protein shell, may extend molecular ultrasound imaging capability and find substantial values in therapy. In this study, we investigated the fundamental acoustic characteristics, including attenuation and non-linear property of NGV. Resonance frequency was obtained by measuring the attenuation coefficient of NGV using pulse-echo system and found to be at high frequency region greater than 80MHz. By testing the non-linear property of NGV, it shows significant second harmonic frequency when sonicated by 40MHz ultrasound signal. The stability is well enhanced without significant broken for more than 6 hrs. With the advantage of nanometer size, good ultrasonic contrast and enhanced stability, it is believed to perform extravascular molecular imaging with ultrasound modality.
ISBN: 978-1-4799-8182-3 (electronic)
978-1-4799-8181-6 (DVD)
978-1-4799-8183-0 (print on demand (PoD))
DOI: 10.1109/ULTSYM.2015.0386
Appears in Collections:Conference Paper

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