Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/63004
Title: The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis
Authors: Xiao, C
Lu, C
Zhao, LH
Liu, ZL
Zhang, WD
He, YH
Chen, SL
Tang, JCO 
Chan, ASC
Lu, AP
Keywords: Triptolide
Peyer’s patch
IEL
LPL
Collagen-induced arthritis
Issue Date: 2006
Publisher: Georg Thieme Verlag
Source: Planta medica, 2006, v. 72, no. 14, p. 1268-1272 How to cite?
Journal: Planta medica 
Abstract: For investigating the effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis (CIA), the changes of the Peyer’s patches, IEL (intraepithelial lymphocytes), LPL (lamina propria lymphocytes), periphery lymphocytes, and levels of TGF-β in CIA mice were checked with flow cytometry or ELISA. Our results showed that triptolide could lower the arthritic scores and increase TGF-β level. Triptolide also had an effect on enteric mucosal immune lymphocytes in Peyer’s patch, IEL and LPL of CIA mice. The regulation of enteric mucosal lymphocytes might explain some of the immunosuppressive activities of triptolide.
URI: http://hdl.handle.net/10397/63004
ISSN: 0032-0943
DOI: 10.1055/s-2006-947240
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