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Title: Detection limits of confocal surface plasmon microscopy
Authors: Pechprasarn, S
Somekh, MG 
Issue Date: 2014
Publisher: Optical Society of America
Source: Biomedical optics express, 2014, v. 5, no. 6, p. 1744-1756 How to cite?
Journal: Biomedical optics express 
Abstract: This paper applies rigorous diffraction theory to evaluate the minimum mass sensitivity of a confocal optical microscope designed to excite and detect surface plasmons operating on a planar metallic substrate. The diffraction model is compared with an intuitive ray picture which gives remarkably similar predictions. The combination of focusing the surface plasmons and accurate phase measurement mean that under favorable but achievable conditions detection of small numbers of molecules is possible, however, we argue that reliable detection of single molecules will benefit from the use of structured surfaces. System configurations needed to optimize performance are discussed.
ISSN: 2156-7085
DOI: 10.1364/BOE.5.001744
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